Format

Send to

Choose Destination
See comment in PubMed Commons below
Commun Integr Biol. 2010 Sep;3(5):443-6. doi: 10.4161/cib.3.5.12287.

Synaptic activity-responsive element (SARE): A unique genomic structure with an unusual sensitivity to neuronal activity.

Author information

1
Department of Neurochemistry; University of Tokyo Graduate School of Medicine; Bunkyo-ku, Tokyo Japan.

Abstract

Formation of a new memory requires plasticity at the synaptic level. However, it has also been shown that the consolidation and the maintenance of such a new memory involve processes that necessitate active mRNA at the nucleus of the cell. How can robust changes in synaptic efficacy specifically drive new transcription and translation of new gene transcripts, and thus transform an otherwise transient plasticity into a long-lasting and stable one? In this article, we highlight the conceptual advance that was gained by the discovery of a potent Synaptic Activity-Responsive Element (SARE) found ∼7 kb upstream of the transcription initiation site of the neuronal immediate early gene Arc. The unique genomic structure of SARE, which contained adjacent and cooperative binding sites for three major activity-dependent transcription factors within a 100-bp locus, was associated with an unusual responsiveness to neuronal stimuli. Taken together, these findings shed light on a new class of transcriptional sensor with enhanced sensitivity to synaptic activity.

KEYWORDS:

Arc; CREB; CaMK; MEF2; SRF; calcium; plasticity; synaptic activity

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Support Center