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FEBS Lett. 2011 Jul 7;585(13):2129-36. doi: 10.1016/j.febslet.2010.11.002. Epub 2010 Nov 5.

An overview of epigenetics and chemoprevention.

Author information

1
Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, United States. yi-wen.huang@osumc.edu

Abstract

It is now appreciated that both genetic alteration, e.g. mutations, and aberrant epigenetic changes, e.g. DNA methylation, cause cancer. Epigenetic dysregulation is potentially reversible which makes it attractive as targets for cancer prevention. Synthetic drugs targeting enzymes, e.g. DNA methyltransferase and histone deacetylase, that regulate epigenetic patterns are active in clinical settings. In addition, dietary factors have been suggested to have potential to reverse aberrant epigenetic patterns. Uncovering the human epigenome can lead us to better understand the dynamics of DNA methylation in disease progression which can further assist in cancer prevention.

PMID:
21056563
PMCID:
PMC3071863
DOI:
10.1016/j.febslet.2010.11.002
[Indexed for MEDLINE]
Free PMC Article
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