Format

Send to

Choose Destination
See comment in PubMed Commons below
Nature. 1990 Feb 8;343(6258):536-40.

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels.

Author information

1
Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02254.

Abstract

Mutations in the period (per) gene of Drosophila melanogaster affect both circadian and ultradian rhythms. Levels of per gene product undergo circadian oscillation, and it is now shown that there is an underlying oscillation in the level of per RNA. The observations indicate that the cycling of per-encoded protein could result from per RNA cycling, and that there is a feedback loop through which the activity of per-encoded protein causes cycling of its own RNA.

PMID:
2105471
DOI:
10.1038/343536a0
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center