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J Thromb Thrombolysis. 2011 May;31(4):449-57. doi: 10.1007/s11239-010-0529-6.

Acquired factor V inhibitors: a systematic review.

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1
Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy. mfranchini@ao.pr.it

Abstract

The occurrence of an inhibitor against coagulation factor V (FV) is a rare but challenging condition, which may span from asymptomatic laboratory abnormalities to potentially life-threatening bleeding. The onset of FV inhibitors has been associated most frequently in the past with the patients' exposure to topical bovine thrombin administered during surgery procedures. However, since this preparation is no longer used, in this systematic review we have only focused on non-bovine thrombin-related FV inhibitor cases.

PMID:
21052780
DOI:
10.1007/s11239-010-0529-6
[Indexed for MEDLINE]
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