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Trends Microbiol. 2011 Jan;19(1):33-9. doi: 10.1016/j.tim.2010.10.002. Epub 2010 Nov 1.

Persistence of human papillomavirus infection: keys to malignant progression.

Author information

1
Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, 303 E. Chicago Ave, Morton 6-693, Chicago, IL 60611, USA.

Abstract

Human papillomaviruses (HPVs) are the etiologic agents of cervical and other epithelial cancers. Persistence of infections by high-risk HPV types is the single greatest risk factor for malignant progression. Although prophylactic vaccines have been developed that target high-risk HPV types, there is a continuing need to understand better the virus-host interactions that underlie persistent benign infection and progression to cancer. In this review we summarize the molecular events that facilitate the differentiation-dependent HPV life cycle, how the life cycle is organized to facilitate virus persistence, and how the activities of HPV regulatory proteins result in malignancy.

PMID:
21050765
PMCID:
PMC3059725
DOI:
10.1016/j.tim.2010.10.002
[Indexed for MEDLINE]
Free PMC Article

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