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Science. 1978 Sep 1;201(4358):819-21.

Trisodium phosphonoformate, a new antiviral compound.

Abstract

Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.

PMID:
210500
DOI:
10.1126/science.210500
[Indexed for MEDLINE]

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