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J Virol. 2011 Jan;85(2):1151-5. doi: 10.1128/JVI.01821-10. Epub 2010 Nov 3.

Complement opsonization enhances friend virus infection of B cells and thereby amplifies the virus-specific CD8+ T cell response.

Author information

1
Division of Virology, Innsbruck Medical University, Fritz-Pregl Str. 3, 6020 Innsbruck, Austria.

Abstract

B cells are one of the targets of Friend virus (FV) infection, a well-established mouse model often used to study retroviral infections in vivo. Although B cells may be effective in stimulating cytotoxic T lymphocyte responses, studies involving their role in FV infection have mainly focused on neutralizing antibody production. Here we show that polyclonal activation of B cells promotes their infection with FV both in vitro and in vivo. Furthermore, we demonstrate that complement opsonization of Friend murine leukemia virus (F-MuLV) enhances infection of B cells, which correlates with increased potency of B cells to activate FV-specific CD8(+) T cells.

PMID:
21047954
PMCID:
PMC3019994
DOI:
10.1128/JVI.01821-10
[Indexed for MEDLINE]
Free PMC Article
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