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Nord J Psychiatry. 2011 Jun;65(3):203-7. doi: 10.3109/08039488.2010.525258. Epub 2010 Nov 3.

No association of the neuropeptide Y (Leu7Pro) and ghrelin gene (Arg51Gln, Leu72Met, Gln90Leu) single nucleotide polymorphisms with eating disorders.

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1
Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University Vienna, Vienna, Austria.

Abstract

BACKGROUND:

Genetic factors likely contribute to the biological vulnerability of eating disorders.

AIMS:

Case-control association study on one neuropeptide Y gene (Leu7Pro) polymorphism and three ghrelin gene (Arg51Gln, Leu72Met and Gln90Leu) polymorphisms.

METHODS:

114 eating disorder patients (46 with anorexia nervosa, 30 with bulimia nervosa, 38 with binge eating disorder) and 164 healthy controls were genotyped.

RESULTS:

No differences were detected between patients and controls for any of the four polymorphisms in allele frequency and genotype distribution (P > 0.05). Allele frequencies and genotypes had no significant influence on body mass index (P > 0.05) in eating disorder patients.

CONCLUSION:

Positive findings of former case-control studies of associations between ghrelin gene polymorphisms and eating disorders could not be replicated. Neuropeptide Y gene polymorphisms have not been investigated in eating disorders before.

PMID:
21047193
DOI:
10.3109/08039488.2010.525258
[Indexed for MEDLINE]
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