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Glia. 2011 Jan;59(1):26-34. doi: 10.1002/glia.21073.

Functional heterotypic interactions between astrocyte and oligodendrocyte connexins.

Author information

1
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Human genetic diseases and mouse knockouts illustrate that the maintenance of central nervous system myelin requires connexin expression by both astrocytes and oligodendrocytes. Because these cell types express nonoverlapping sets of connexins, the intercellular channels formed between them must be asymmetric with regard to connexin content, defined as heterotypic. Here, we show that oligodendrocyte Cx47 can form heterotypic channels with astrocyte Cx43 or Cx30 but not Cx26, whereas oligodendrocyte Cx32 can functionally interact with astrocyte Cx30 or Cx26 but not Cx43. Thus, as many as four types of intercellular channels could be formed between astrocytes and oligodendrocytes.

PMID:
21046554
PMCID:
PMC3022368
DOI:
10.1002/glia.21073
[Indexed for MEDLINE]
Free PMC Article

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