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Br J Cancer. 2010 Nov 23;103(11):1755-9. doi: 10.1038/sj.bjc.6605965. Epub 2010 Nov 2.

Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition.

Author information

1
Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, OX3 7LF Oxford, UK. kostas.tsilidis@ceu.ox.ac.uk

Abstract

BACKGROUND:

Oral contraceptive use and reproductive factors may initiate long-term changes to the hormonal milieu and thereby, possibly influence colorectal cancer risk.

METHODS:

We examined the association of hormonal and reproductive factors with risk of colorectal cancer among 337,802 women in the European Prospective Investigation into Cancer and Nutrition, of whom 1878 developed colorectal cancer.

RESULTS:

After stratification for center and age, and adjustment for body mass index, smoking, diabetes mellitus, physical activity and alcohol consumption, ever use of oral contraceptives was marginally inversely associated with colorectal cancer risk (hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.83-1.02), although this association was stronger among post-menopausal women (HR, 0.84; 95% CI: 0.74-0.95). Duration of oral contraceptive use and reproductive factors, including age at menarche, age at menopause, type of menopause, ever having an abortion, parity, age at first full-term pregnancy and breastfeeding, were not associated with colorectal cancer risk.

CONCLUSION:

Our findings provide limited support for a potential inverse association between oral contraceptives and colorectal cancer risk.

PMID:
21045829
PMCID:
PMC2994229
DOI:
10.1038/sj.bjc.6605965
[Indexed for MEDLINE]
Free PMC Article

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