Send to

Choose Destination
Mol Interv. 2010 Oct;10(5):305-12. doi: 10.1124/mi.10.5.7.

Strontium ranelate in osteoporosis and beyond: identifying molecular targets in bone cell biology.

Author information

Laboratory of Osteoblast Biology and Pathology, Inserm U606, Paris, France.


Osteoporosis is characterized by reduced bone mass and deterioration of bone microarchitecture, resulting in bone fragility and increased susceptibility to fractures. Current antiosteoporotic treatments depend on antiresorptive or anabolic drugs, but a novel modality of treatment appears to be mediated by strontium ranelate, which has been shown to act by opposing bone resorption and formation in vitro. This review article addresses the cellular and molecular mechanisms that have been implicated in the therapeutic strengthening of bone observed upon administration of strontium ranelate to osteoporotic patients. These mechanisms relate to specific pathways of calcium signaling, including complex networks involving nuclear factor of activated T cells (NFAT) and Wnt signaling.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center