Format

Send to

Choose Destination
See comment in PubMed Commons below
Mol Interv. 2010 Oct;10(5):271-81. doi: 10.1124/mi.10.5.4.

Age-related macular degeneration: genetic and environmental factors of disease.

Author information

1
Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, China.

Abstract

Age-related macular degeneration (AMD) is the most common cause of visual impairment among the elderly in developed countries, and its prevalence is thus increasing as the population ages; however, treatment options remain limited because the etiology and pathogenesis of AMD are incompletely defined. Recently, much progress has been made in gene discovery and mechanistic studies, which clearly indicate that AMD involves the interaction of multiple genetic and environmental factors. The identification of genes that have a substantial impact on the risk for AMD is not only facilitating the diagnosis and screening of populations at risk but is also elucidating key molecular pathways of pathogenesis. Pharmacogenetic studies of treatment responsiveness among patients with the "wet" form of AMD are increasingly proving to be clinically relevant; pharmacogenetic approaches hold great promise for both identifying patients with the best chance for vision recovery as well as tailoring individualized therapies.

PMID:
21045241
PMCID:
PMC3002218
DOI:
10.1124/mi.10.5.4
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center