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J Geriatr Psychiatry Neurol. 2010 Dec;23(4):213-27. doi: 10.1177/0891988710383571.

Genetics of Alzheimer disease.

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1
Department of Medicine, University of Washington School of Medicine, Seattle, WA 98108, USA.

Abstract

Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances. Three causative genes have been associated with autosomal dominant familial AD (APP, PSEN1, and PSEN2) and 1 genetic risk factor (APOEε4 allele). Identification of these genes has led to a number of animal models that have been useful to study the pathogenesis underlying AD. In this article, we provide an overview of the clinical and genetic features of AD.

PMID:
21045163
PMCID:
PMC3044597
DOI:
10.1177/0891988710383571
[Indexed for MEDLINE]
Free PMC Article
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