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J Young Pharm. 2010 Jul;2(3):269-72. doi: 10.4103/0975-1483.66808.

Evaluation of the effect of lime fruit juice on the anticoagulant effect of warfarin.

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Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.



Citrus aurantifolia (Family Rutaceae) is commonly known as a familiar food and medicine, and s therapeutic effectiveness in a variety of diseases has been suggested in traditional medicine. Various complementary and alternative medicines (CAM) have been shown to interact with orthodox medicines. Hence, the aim of this study is to investigate such a phenomenon particularly the interaction of lime fruit juice with warfarin.


Wistar strain albino rats of both sexes weighing between 190 and 230g were administered with oral doses of the respective drugs used depending on the groups of animals. Effects on the anticoagulant activity of warfarin were determined by standard laboratory methods.


Lime fruit juice caused a reduction in the anticoagulant activity of warfarin.


This finding has shown that CAM can interact with orthodox medicines hence, warfarin prescribers need to be aware of the usage of CAM and monitor the international normalized ratio (INR) of their patients more frequently.


Anticoagulant; complementary and alternative medicines; interaction; lime fruit; therapeutic effectiveness; traditional medicine; warfarin

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