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J Young Pharm. 2010 Jul;2(3):234-9. doi: 10.4103/0975-1483.66794.

Formulation development, evaluation and comparative study of effects of super disintegrants in cefixime oral disintegrating tablets.

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1
Nazareth College of Pharmacy, Othera P.O, Thiruvalla, Pathanamthitta (Dist.), Kerala - 689 546, India.

Abstract

The present work was aimed at formulation development, evaluation and comparative study of the effects of superdisintegrants in Cefixime 50 mg oral disintegrating tablets. The superdisintegrants used for the present study were sodium starch glycolate and crosscarmellose sodium. The formulated tablets were evaluated for various tableting properties, like hardness, thickness, friability, weight variation, disintegration time and dissolution rate. Comparative evaluation of the above-mentioned parameters established the superiority of the tablets formulated with crosscarmellose sodium to those formulated with sodium starch glycolate.

KEYWORDS:

Cefixime; oral disintegrating tablets; superdisintegrants

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