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Antimicrob Agents Chemother. 2011 Jan;55(1):382-4. doi: 10.1128/AAC.01259-10. Epub 2010 Nov 1.

Cytomegalovirus UL97 mutations affecting cyclopropavir and ganciclovir susceptibility.

Author information

1
Division of Infectious Diseases, Oregon Health and Science University, Portland, OR, USA. chous@ohsu.edu

Abstract

Among the 7 most common UL97 mutations encountered in ganciclovir-resistant clinical cytomegalovirus isolates, the associated cyclopropavir cross-resistance varies from insignificant (L595S) to substantial (M460I and H520Q) as determined by recombinant phenotyping. Mutations M460I and H520Q were preferentially selected in vitro under cyclopropavir and conferred 12- to 20-fold increases in 50% effective concentration (EC(50)) values, while M460V, C592G, A594V, and C603W conferred 3- to 5-fold increases. Uncommon mutations M460T and C603R increased cyclopropavir EC(50)s by 8- to 10-fold.

PMID:
21041510
PMCID:
PMC3019618
DOI:
10.1128/AAC.01259-10
[Indexed for MEDLINE]
Free PMC Article

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