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J Cell Biol. 2010 Nov 1;191(3):443-52. doi: 10.1083/jcb.201008163.

The cell biology of smell.

Author information

1
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA.

Abstract

The olfactory system detects and discriminates myriad chemical structures across a wide range of concentrations. To meet this task, the system utilizes a large family of G protein-coupled receptors-the odorant receptors-which are the chemical sensors underlying the perception of smell. Interestingly, the odorant receptors are also involved in a number of developmental decisions, including the regulation of their own expression and the patterning of the olfactory sensory neurons' synaptic connections in the brain. This review will focus on the diverse roles of the odorant receptor in the function and development of the olfactory system.

PMID:
21041441
PMCID:
PMC3003330
DOI:
10.1083/jcb.201008163
[Indexed for MEDLINE]
Free PMC Article

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