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J Cell Biol. 2010 Nov 1;191(3):439-41. doi: 10.1083/jcb.201009093.

Revisiting caveolin trafficking: the end of the caveosome.

Author information

1
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. R.Parton@imb.uq.edu.au

Abstract

In this issue, a study by Hayer et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201003086) provides insights into the trafficking of caveolins, the major membrane proteins of caveolae. As well as providing evidence for ubiquitin-mediated endosomal sorting and degradation of caveolin in multivesicular bodies (MVBs), the new findings question the existence of a unique organelle proposed nine years ago, the caveosome.

PMID:
21041440
PMCID:
PMC3003311
DOI:
10.1083/jcb.201009093
[Indexed for MEDLINE]
Free PMC Article

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