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Cell Stem Cell. 2010 Nov 5;7(5):559-64. doi: 10.1016/j.stem.2010.10.007.

Different flavors of pluripotency, molecular mechanisms, and practical implications.

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1
Center for Regenerative Medicine, Harvard Medical School, Massachusetts General Hospital, CPZN-4256, 185 Cambridge Street, Boston, MA 02114, USA.

Erratum in

  • Cell Stem Cell. 2010 Dec 3;7(6):759.

Abstract

Pluripotent stem cells (PSCs) have been classified into two distinct states: a primitive, naive LIF-dependent state represented by murine ESCs, and a primed bFGF-dependent state observed in murine and rat epiblast stem cells (EpiSCs). The vast similarities between EpiSCs and human ESCs suggest that, despite their blastocyst origin, human ESCs exist in a primed pluripotent state. Recent findings demonstrate that the naive and primed pluripotent states are interconvertible, even in human cells, and hint that growth factor-mediated Nanog expression may be an important factor regulating the balance between them.

PMID:
21040897
DOI:
10.1016/j.stem.2010.10.007
[Indexed for MEDLINE]
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