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BJOG. 2010 Dec;117(13):1593-8. doi: 10.1111/j.1471-0528.2010.02742.x. Epub 2010 Oct 13.

Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia.

Author information

1
Department of Maternal Fetal Medicine, BC Women's Hospital, Vancouver, BC, Canada. awshand@yahoo.com.au

Abstract

OBJECTIVE:

To determine in a group of pregnant women if vitamin D status, based on serum 25-hydroxyvitamin D (25OHD) concentration, was associated with a subsequent risk of pre-eclampsia or adverse pregnancy outcomes.

DESIGN:

Prospective cohort study.

SETTING:

Vancouver, British Columbia, Canada (49°N).

POPULATION:

Women attending a specialist antenatal clinic because of clinical or biochemical risk factors for pre-eclampsia (n = 221).

METHODS:

Serum 25OHD concentration measured between 10 and 20 weeks of gestation.

MAIN OUTCOME MEASURES:

Pre-eclampsia and composite adverse pregnancy outcomes.

RESULTS:

Of the women, 78% were vitamin D insufficient (25OHD <75 nmol/l) and 53% were vitamin D deficient (25OHD <50 nmol/l). There was no difference in the rates of pre-eclampsia, gestational hypertension, preterm birth or composite adverse pregnancy outcomes by 25OHD concentration.

CONCLUSIONS:

Vitamin D deficiency and insufficiency were common in a group of women at high risk of pre-eclampsia; however, it was not associated with subsequent risk of an adverse pregnancy outcome.

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