Format

Send to

Choose Destination
J Eur Acad Dermatol Venereol. 2011 Jul;25(7):782-7. doi: 10.1111/j.1468-3083.2010.03860.x. Epub 2010 Oct 6.

Relationship between smoking-induced oxidative stress and the clinical severity of psoriasis.

Author information

1
Department of Dermatology & Venereology Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt. drenayatattwa@yahoo.com

Abstract

BACKGROUND:

Psoriasis is a chronic and recurrent inflammatory skin disease, known as an oxidative stress condition. Smoking augments the risk of development of psoriasis. Although the relative importance of potential mechanisms of smoking-induced psoriasis is unknown, direct delivery of oxidants has been implicated in the pathogenesis of smoking-induced psoriasis.

OBJECTIVES:

This study aimed to investigate the smoking-induced oxidative stress in psoriatic patients and its correlation with the severity of the disease.

METHODS:

The levels of malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in 25 psoriatic patients (10 smokers, 10 non-smokers and 5 ex-smokers) and 20 healthy control subjects (10 smokers and 10 non-smokers). Clinical severity of psoriasis was determined according to the Psoriasis Area Severity Index (PASI) score.

RESULTS:

Our results showed a significant increase in serum MDA and decrease in the blood SOD levels in psoriatic patients compared with those in control subjects and those in smokers compared with those in non-smokers. The concentrations of MDA and SOD were significantly correlated with PASI score. There was a significant increase in PASI score in smoker patients compared with that in non-smokers and it increased with increasing the pack-years of smoking.

CONCLUSIONS:

Our results indicate that smoking-induced oxidative damage resulting from increased reactive oxygen species production along with insufficient capacity of antioxidant mechanisms may be involved in the pathogenesis of psoriasis.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center