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Contact Dermatitis. 2010 Dec;63(6):347-56. doi: 10.1111/j.1600-0536.2010.01777.x. Epub 2010 Oct 7.

The lactic acid stinging test predicts susceptibility to cumulative irritation caused by two lipophilic irritants.

Author information

1
Department of Dermatology, University Hospital Jena, Jena, Germany. sibylle.schliemann@med.uni-jena.de

Abstract

BACKGROUND:

Skin exposure to lipophilic irritants at workplaces is a risk factor for the development of occupational irritant hand dermatitis. Suitable lipophilic model irritants to be used in repeated irritation studies in volunteers are needed to gain a better understanding of the chemical-dependent mechanisms of skin irritation.

OBJECTIVES:

To investigate acute and cumulative irritation elicited by two new lipophilic model irritants, octane (CAS No. 111-65-9) and cumene (CAS No. 98-82-8), in stingers as compared with non-stingers.

METHODS:

Short-time occlusive and repetitive occlusive irritation patch tests were performed over 5 days with octane and cumene in two groups of healthy volunteers (n = 15 each) who were classified as stingers and non-stingers according to a preceding lactic acid stinging test. Acute and cumulative irritation was quantified using clinical assessments and bioengineering methods (laser Doppler flowmetry, transepidermal water loss, capacitance measurements, and skin colour reflectance).

RESULTS:

Significantly stronger cumulative irritation was observed in stingers than in non-stingers for both irritants (visual scoring, stratum corneum hydration, and skin colour reflectance).

CONCLUSIONS:

The preliminary results suggest the existence of a distinct sub-population with increased susceptibility to cumulative irritation induced by lipophilic irritants that can be identified by the lactic acid stinging test.

[Indexed for MEDLINE]

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