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Aust N Z J Obstet Gynaecol. 2010 Oct;50(5):485-90. doi: 10.1111/j.1479-828X.2010.01196.x.

The frequency of early, spontaneous miscarriage associated with the leu33pro polymorphism of Glycoprotein IIIa: a pilot study.

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  • 12nd Department of Obstetrics and Gynecology, DNA analysis, Hormonal and Biochemical Laboratory, University of Athens, Aretaieio Hospital, Laiko Hospital, Athens, Greece.



Inherited thrombophilia is associated with both poor obstetrical outcomes and increased cardiovascular risk later in life. In fact, a personal history of spontaneous miscarriage is reported to increase the risk of subsequent ischaemic heart disease.


This pilot study aims to evaluate the association between genetic polymorphism-related increased risk of arterial thrombosis and the history of spontaneous miscarriage early in pregnancy, among healthy postmenopausal women.


The following polymorphisms were assessed in 84 healthy post-menopausal women: Glycoprotein IIIa leu33pro, Apolipoprotein E2/E3/E4, Methylenetetrahydrofolate reductase, Apolipoprotein B arg3500gln, Paraoxonase 1 gln182arg, Plasminogen activator inhibitor 1 4G/5G, Cholesterol-7(α) -hydroxylase and Cholesterol ester transfer protein (ΤaqIB) B1/B2. The association between the polymorphisms and history of spontaneous pregnancy loss was evaluated.


The frequency of the PL(A2) allele of glycoprotein IIIa was significantly higher in women who experienced spontaneous miscarriage when compared with controls (P = 0.033). Glycoprotein IIIa leu33pro polymorphism correlated positively with the frequency of spontaneous miscarriage (P = 0.027). Among women reporting miscarriage, 55.6% were heterozygous compared with 44.4% who were wild type. We found no significant association between any of the other polymorphisms and spontaneous pregnancy loss.


Our findings indicate that Glycoprotein IIIa leu33pro polymorphism is associated with early, spontaneous miscarriage. The causative role of this polymorphism as a risk factor of pregnancy loss needs further investigation by prospective studies.

[PubMed - indexed for MEDLINE]
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