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Curr Genomics. 2010 May;11(3):184-98. doi: 10.2174/138920210791110979.

Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications.

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Karlsruher Institute of Technology, Institute of Toxicology and Genetics, Karlsruhe PO-Box 3640, 76021 Karlsruhe, Germany.


Damage to the genetic material can affect cellular function in many ways. Therefore, maintenance of the genetic integrity is of primary importance for all cells. Upon DNA damage, cells respond immediately with proliferation arrest and repair of the lesion or apoptosis. All these consequences require recognition of the lesion and transduction of the information to effector systems. The accomplishment of DNA repair, but also of cell cycle arrest and apoptosis furthermore requires protein-protein interactions and the formation of larger protein complexes. More recent research shows that the formation of many of these aggregates depends on post-translational modifications. In this article, we have summarized the different cellular events in response to a DNA double strand break, the most severe lesion of the DNA.


DNA double strand breaks; cell cycle arrest; homologous recombination; non-homologous endjoining; post-translational modifications.

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