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Nat Genet. 2010 Dec;42(12):1126-1130. doi: 10.1038/ng.696. Epub 2010 Oct 31.

A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).

Author information

1
Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
2
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK.
3
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
4
Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
5
Department of Pathology & Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
6
Epidemiology & Genetics Unit, Department of Health Sciences, University of York, York, YO10 5DD, UK.
7
Department of Epidemiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
8
Department of Experimental Therapy, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
9
University Hospital of Cologne, Department of Internal Medicine, Cologne, Germany.
10
Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Centre Groningen, University of Groningen, the Netherlands.
11
Unit of Clinical Epidemiology, Department of Medicine, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.
12
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
13
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
14
Department of Radiotherapy, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
15
Department of Pathology and Oncology, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
16
Department of Oncology, Radiology and Clinical Immunology, Uppsala University, SE-751 85, Uppsala, Sweden.
17
Institute of Pathology, Aarhus University Hospital, DK-8000, Aarhus, Denmark.
18
Department of Clinical Immunology, University Hospital of Copenhagen, Rigshospitalet, DK-2100, Copenhagen, Denmark.
19
Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden.
20
Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark.
21
Cancer Prevention Institute of California, Fremont, CA 94538.
22
Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA.
23
Cancer Immunogenetics Group, School of Cancer & Enabling Sciences, University of Manchester, Research Floor, St Mary's Hospital, Manchester, M13 9WL, UK.
24
Section of Epidemiology, Institute of Cancer Research, Sutton, SM2 5NG, UK.
25
Department of Genetics University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
26
Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
27
The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.
#
Contributed equally

Abstract

To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10(-50)). These data provide new insight into the pathogenesis of cHL.

PMID:
21037568
PMCID:
PMC4268499
DOI:
10.1038/ng.696
[Indexed for MEDLINE]
Free PMC Article

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