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Nat Rev Rheumatol. 2010 Nov;6(11):617-8. doi: 10.1038/nrrheum.2010.162.

Osteoarthritis: Small studies overestimate the benefit of therapies for OA.

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1
Division of Rheumatology, University Hospitals of Geneva, Avenue Beau-Séjour 26, CH-1211 Geneva 14, Switzerland. A. Finckhaxel.finckh@hcuge.ch

Abstract

a meta-epidemiological study has revealed that the inclusion of small studies in meta-analyses of osteoarthritis interventions could lead to an overestimation of the benefit of these interventions. Does this mean meta-analyses should be restricted to trials with large sample sizes?

PMID:
21037558
DOI:
10.1038/nrrheum.2010.162
[Indexed for MEDLINE]
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