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Appl Environ Microbiol. 2011 Jan;77(1):320-2. doi: 10.1128/AEM.02049-10. Epub 2010 Oct 29.

Production of glutaconic acid in a recombinant Escherichia coli strain.

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1
Fachbereich Biologie, Philipps-Universit├Ąt, Marburg, Germany.

Abstract

The assembly of six genes that encode enzymes from glutamate-fermenting bacteria converted Escherichia coli into a glutaconate producer when grown anaerobically on a complex medium. The new anaerobic pathway starts with 2-oxoglutarate from general metabolism and proceeds via (R)-2-hydroxyglutarate, (R)-2-hydroxyglutaryl-coenzyme A (CoA), and (E)-glutaconyl-CoA to yield 2.7 ┬▒ 0.2 mM (E)-glutaconate in the medium.

PMID:
21037290
PMCID:
PMC3019735
DOI:
10.1128/AEM.02049-10
[Indexed for MEDLINE]
Free PMC Article
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