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Mayo Clin Proc. 2010 Nov;85(11):1016-20. doi: 10.4065/mcp.2009.0040.

Hantavirus infection: a neglected diagnosis in thrombocytopenia and fever?

Author information

1
Division of Hematology, Oncology, Immunology, Rheumatology, and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany.

Abstract

Thrombocytopenia, fever, and acute renal failure are characteristic features of nephropathia epidemica, the predominant hantavirus infection in Europe. However, clinical presentation and blood cell counts may point to other disorders, such as a hematologic disease, particularly when impairment of renal function is not evident. This differential diagnosis often results in further extensive and unnecessary testing. We describe 3 patients with hantavirus infection with no renal failure, in whom a hematologic disorder was initially suspected. Serologic testing of hantavirus finally unraveled the mystery, and outcome of the patients was excellent. It is conceivable that similar cases often remain undiagnosed. Thus, testing for hantavirus should always be considered in cases of thrombocytopenia and fever of unknown origin, especially in areas endemic for the infection.

PMID:
21037045
PMCID:
PMC2966365
DOI:
10.4065/mcp.2009.0040
[Indexed for MEDLINE]
Free PMC Article
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