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Bioorg Med Chem Lett. 2010 Dec 15;20(24):7512-5. doi: 10.1016/j.bmcl.2010.09.139. Epub 2010 Oct 14.

1,2,3-triazolyl amino acids as AMPA receptor ligands.

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1
Discipline of Chemistry, The University of Adelaide, Adelaide, Australia.

Abstract

The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.

PMID:
21036612
DOI:
10.1016/j.bmcl.2010.09.139
[Indexed for MEDLINE]
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