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Trends Microbiol. 2010 Dec;18(12):569-76. doi: 10.1016/j.tim.2010.09.007. Epub 2010 Oct 28.

Aspergillus nidulans asexual development: making the most of cellular modules.

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Department of Applied Chemistry, Faculty of Chemistry, University of The Basque Country, Manuel de Lardizabal, 3, 20018, San Sebastian, Spain.


Asexual development in Aspergillus nidulans begins in superficial hyphae as the programmed emergence of successive pseudohyphal modules, collectively known as the conidiophore, and is completed by a layer of specialized cells (phialides) giving rise to chains of aerial spores. A discrete number of regulatory factors present in hyphae play different stage-specific roles in pseudohyphal modules, depending on their cellular localization and protein-protein interactions. Their multiple roles include the timely activation of a sporulation-specific pathway that governs phialide and spore formation. Such functional versatility provides for a new outlook on morphogenetic change and the ways we should study it.

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