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J Allergy Clin Immunol. 2010 Dec;126(6):1191-7. doi: 10.1016/j.jaci.2010.08.036. Epub 2010 Oct 28.

Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants.

Author information

1
Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY, USA. scott.sicherer@mssm.edu

Abstract

BACKGROUND:

Peanut allergy is typically severe, lifelong, and prevalent.

OBJECTIVE:

To identify factors associated with peanut sensitization.

METHODS:

We evaluated 503 infants 3 to 15 months of age (mean, 9.4 months) with likely milk or egg allergy but no previous diagnosis of peanut allergy. A total of 308 had experienced an immediate allergic reaction to cow's milk and/or egg, and 204 had moderate to severe atopic dermatitis and a positive allergy test to milk and/or egg. A peanut IgE level ≥5 kU(A)/L was considered likely indicative of peanut allergy.

RESULTS:

A total of 140 (27.8%) infants had peanut IgE levels ≥5 kU(A)/L. Multivariate analysis including clinical, laboratory, and demographic variables showed frequent peanut consumption during pregnancy (odds ratio, 2.9; 95% CI, 1.7-4.9; P < .001), IgE levels to milk (P = .001) and egg (P < .001), male sex (P = .02), and nonwhite race (P = .02) to be the primary factors associated with peanut IgE ≥5 kUA/L. Frequency of peanut consumption during pregnancy and breast-feeding showed a dose-response association with peanut IgE ≥5 kU(A)/L, but only consumption during pregnancy was a significant predictor. Among 71 infants never breast-fed, frequent consumption of peanut during pregnancy was strongly associated with peanut IgE ≥5 kU(A)/L (odds ratio, 4.99, 95% CI, 1.69-14.74; P < .004).

CONCLUSION:

In this cohort of infants with likely milk or egg allergy, maternal ingestion of peanut during pregnancy was strongly associated with a high level of peanut sensitization.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00356174.

PMID:
21035177
PMCID:
PMC3018157
DOI:
10.1016/j.jaci.2010.08.036
[Indexed for MEDLINE]
Free PMC Article

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