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Adv Immunol. 2010;107:31-69. doi: 10.1016/B978-0-12-381300-8.00002-2.

Innate signaling networks in mucosal IgA class switching.

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Department of Medicine, The Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA.


The past 20 years have seen a growing interest over the control of adaptive immune responses by the innate immune system. In particular, considerable attention has been paid to the mechanisms by which antigen-primed dendritic cells orchestrate the differentiation of T cells. Additional studies have elucidated the pathways followed by T cells to initiate immunoglobulin responses in B cells. In this review, we discuss recent advances on the mechanisms by which intestinal bacteria, epithelial cells, dendritic cells, and macrophages cross talk with intestinal T cells and B cells to induce frontline immunoglobulin A class switching and production.

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