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Wei Sheng Yan Jiu. 2010 Sep;39(5):643-6.

[Lead exposure markers and related susceptibility genes based on different people].

[Article in Chinese]

Author information

  • 1Department of Environmental Health, School of Public Health, Fudan University, Key Laboratory of Public Health and Safety, Ministry of Education, Shanghai 200032, China. seachy@sina.com.cn

Abstract

Lead (Pb) is a toxic heavy metal which exists widely in the environment. Children, pregnant women, the elderly, and other populations, have diverse ways of lead exposure and different toxicokinetics. Moreover, the exposure and effect of lead involve multiple metabolic pathways and mechanisms. Besides ALAD, VDR, HFE genes, the polymorphisms of TF gene and oxidative-stress related genes (Rac2, GPx1, XDH) have been discovered recently to affect lead internal exposure level as well. This review comprehensively describes the characteristics of lead exposure, metabolic characteristics and the lead exposure sensitive markers, of different people groups, and looks forward to the future of the application of Genome-Wide Association Study (GWAS) in this field.

PMID:
21033449
[PubMed - indexed for MEDLINE]
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