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Korean J Urol. 2010 Oct;51(10):729-32. doi: 10.4111/kju.2010.51.10.729. Epub 2010 Oct 21.

Two different renal cell carcinomas and multiple angiomyolipomas in a patient with tuberous sclerosis.

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Department of Urology, Korea University School of Medicine, Seoul, Korea.


We report a case of tuberous sclerosis associated with two histologically different renal cell carcinomas (RCCs) and multiple angiomyolipomas (AMLs) in the same kidney. A 43-year-old female was admitted to our hospital with left flank pain and a huge palpable mass in the left flank area. Abdominal computed tomography revealed two concurrent RCCs and multiple AMLs in the left kidney. Because of the clinical suspicion of RCC, the patient underwent left radical nephrectomy. On gross examination, the total size of the resected left kidney was 30.5×17×8 cm. Microscopically, the upper pole tumor features were consistent with chromophobe RCC and the midpole tumor was a clear-cell RCC. The multifocal masses in the remaining remnant parenchyma were AMLs. Six months after surgery, the patient is healthy without signs of tumor recurrence.


Angiomyolipoma; Clear cell renal carcinoma; Renal cell carcinoma; Tuberous sclerosis

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