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Curr Opin Cell Biol. 2011 Feb;23(1):65-70. doi: 10.1016/j.ceb.2010.09.008. Epub 2010 Oct 26.

Functional interactions between nucleoporins and chromatin.

Author information

1
Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 N. Torrey Pines Road, La Jolla, CA 92037, United States.

Abstract

As the gatekeepers of the eukaryotic cell nucleus, nuclear pore complexes (NPCs) mediate all molecular trafficking between the nucleoplasm and the cytoplasm. In recent years, transport-independent functions of NPC components, nucleoporins, have been identified including roles in chromatin organization and gene regulation. Here, we summarize our current view of the NPC as a dynamic hub for the integration of chromatin regulation and nuclear trafficking and discuss the functional interplay between nucleoporins and the nuclear genome.

PMID:
21030234
PMCID:
PMC3753814
DOI:
10.1016/j.ceb.2010.09.008
[Indexed for MEDLINE]
Free PMC Article

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