Send to

Choose Destination
Curr Opin Cell Biol. 2010 Dec;22(6):722-9. doi: 10.1016/ Epub 2010 Oct 26.

Germ cell sex determination: a collaboration between soma and germline.

Author information

Department of Biology, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.


Sex determination is regulated very differently in the soma vs. the germline, yet both processes are critical for the creation of the male and female gametes. In general, the soma plays an essential role in regulating sexual identity of the germline. However, in some species, such as Drosophila and mouse, the sex chromosome constitution of the germ cells makes an autonomous contribution to germline sexual development. Here we review how the soma and germline cooperate to determine germline sexual identity for some important model systems, the fly, the worm and the mouse, and discuss some of the implications of 'dual control' (soma plus germline) as compared to species where germline sex is dictated only by the surrounding soma.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center