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Immunity. 2010 Oct 29;33(4):504-15. doi: 10.1016/j.immuni.2010.10.004.

Immunologic basis of vaccine vectors.

Author information

1
ProTherImmune, 3656 Happy Valley Road, Lafayette, CA 94549, USA. liu@protherimmune.com

Abstract

Efforts to make vaccines against infectious diseases as well as immunotherapies for cancer, autoimmune diseases and allergy have utilized a variety of heterologous expression systems, including viral and bacterial vectors, as well as DNA and RNA constructs. This review explores the immunologic rationale and provides an update of insights obtained from preclinical and clinical studies of such vaccines.

PMID:
21029961
DOI:
10.1016/j.immuni.2010.10.004
[Indexed for MEDLINE]
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