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Cell. 2010 Oct 29;143(3):341-2. doi: 10.1016/j.cell.2010.10.017.

Ephecting excitatory synapse development.

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1
Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA. dalva@mail.med.upenn.edu

Abstract

Alterations in synapse number and morphology are associated with devastating psychiatric and neurologic disorders. In this issue of Cell, Margolis et al. (2010) show that the RhoA-guanine exchange factor (GEF) Ephexin5 limits the numbers of excitatory synapses that neurons receive, thus identifying a new mechanism controlling synaptogenesis.

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