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Cell. 2010 Oct 29;143(3):341-2. doi: 10.1016/j.cell.2010.10.017.

Ephecting excitatory synapse development.

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Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.


Alterations in synapse number and morphology are associated with devastating psychiatric and neurologic disorders. In this issue of Cell, Margolis et al. (2010) show that the RhoA-guanine exchange factor (GEF) Ephexin5 limits the numbers of excitatory synapses that neurons receive, thus identifying a new mechanism controlling synaptogenesis.

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