Monocytes join the dendritic cell family

Federica Sallusto; Antonio Lanzavecchia

doi:10.1016/j.cell.2010.10.022

Monocytes join the dendritic cell family

Cell. 2010 Oct 29;143(3):339-40. doi: 10.1016/j.cell.2010.10.022.

Authors

Federica Sallusto¹, Antonio Lanzavecchia

Affiliation

¹ Institute for Research in Biomedicine, Bellinzona, Switzerland. federica.sallusto@irb.unisi.ch

PMID: 21029856
DOI: 10.1016/j.cell.2010.10.022

Abstract

Dendritic cells are professional antigen-presenting cells that mediate immunity and tolerance. Cheong et al. (2010) uncover a new route for dendritic cell production in vivo. They show that in response to infection by gram-negative bacteria, monocytes are recruited to the lymph node where they rapidly differentiate into dendritic cells that present antigens to T cells.

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