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Eur J Contracept Reprod Health Care. 2010 Dec;15(6):413-22. doi: 10.3109/13625187.2010.524717. Epub 2010 Oct 28.

Clinical experience with the combined contraceptive vaginal ring in Switzerland, including a subgroup analysis of previous hormonal contraceptive use.

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Reproductive Endocrinology Clinic, Gynaecology Department, University Hospital, Frauenklinikstrasse 10, Zurich, Switzerland.



To collect data on cycle and cycle-related symptoms during a second clinical experience programme with the contraceptive vaginal ring (NuvaRing®) in Switzerland.


Women requiring contraception were recruited by gynaecologists. Questionnaires were used to collect data on cycle and related symptoms, weight, satisfaction and adverse events at baseline and follow-up (typically four cycles).


Of the 1053 women included, 36.9% were starters, 22.4% starters anew, and 40.6% switchers. At follow-up, improvement in cycle regularity was significantly better for starters compared with switchers (18.5% versus 11%; p < 0.001). Starters showed the greatest improvement in bleeding duration and severity. Improvement in the severity of premenstrual symptoms (PMS) and dysmenorrhoea was significantly (p  < 0.001) greater in starters compared with switchers (18.5% vs. 9.1% and 26.5% vs. 9.8%, respectively). Menstrual headache improved in all subgroups. Women were satisfied with changes in weight (92%), cycle control (93.6%) and PMS (86%). Adverse events were reported for 17.5% of women and were most frequently ring-related (such as feeling the ring in situ, vaginal discomfort, ring expulsion).


The data support previous findings that the vaginal ring improves cycle-related symptoms (moderate or severe PMS, dysmenorrhoea, and menstrual headache). Not only starters experienced improvements in symptoms; switchers also benefited.

[Indexed for MEDLINE]

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