Format

Send to

Choose Destination
See comment in PubMed Commons below
Braz J Med Biol Res. 1990;23(8):681-3.

Learning impairment in chronic epileptic rats following pilocarpine-induced status epilepticus.

Author information

1
Departamento de Neurologia e Neurocirurgia, Escola Paulista de Medicina, São Paulo, Brasil.

Abstract

Male Wistar rats were subjected to pilocarpine-induced status epilepticus and allowed to recover. After reaching the chronic state with spontaneous seizures they were tested in an 8-arm radial maze. During learning trials, epileptic rats made significantly more errors than controls. Even in the last trials epileptic rats did not improve their performance, indicating severe learning disability. These results suggest that spontaneous seizures after pilocarpine-induced status epilepticus are a useful model for studying the learning and memory impairment detected in some cases of symptomatic epilepsy.

PMID:
2101094
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center