[Biochemical studies on camomile components/III. In vitro studies about the antipeptic activity of (--)-alpha-bisabolol (author's transl)]

Arzneimittelforschung. 1975 Sep;25(9):1352-4.
[Article in German]

Abstract

(--)-alpha-Bisabolol has a primary antipeptic action depending on dosage, which is not caused by an alteration of the pH-value. The proteolytic activity of pepsin is reduced by 50 percent through addition of bisabolol in the ratio of 1/0.5. The antipeptic action of bisabolol only occurs in case of direct contact. In case of a previous contact with the substrate, the inhibiting effect is lost.

Publication types

  • English Abstract

MeSH terms

  • Dose-Response Relationship, Drug
  • Hemoglobins / metabolism
  • Hydrogen-Ion Concentration
  • In Vitro Techniques
  • Methods
  • Pepsin A / antagonists & inhibitors*
  • Pepsin A / metabolism
  • Plants, Medicinal
  • Sesquiterpenes / pharmacology*
  • Spectrophotometry, Ultraviolet
  • Trichloroacetic Acid
  • Tyrosine / metabolism

Substances

  • Hemoglobins
  • Sesquiterpenes
  • Tyrosine
  • Trichloroacetic Acid
  • Pepsin A