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Cell Cycle. 2010 Nov 1;9(21):4269-75. Epub 2010 Nov 15.

PUMA-mediated tumor suppression: A tale of two stories.

Author information

1
Biocenter, Innsbruck Medical University, Austria. verena.labi@i-med.ac.at

Abstract

Several recent studies provided evidence that PUMA, a pro-apoptotic member of the BH3-only protein subgroup of the Bcl-2 family, is critical for restricting survival and recovery of different cell types, including those of the hematopoietic system, after γ-irradiation (IR)-triggered DNA damage. According to its pro-apoptotic function downstream of p53, PUMA is considered to act as a tumor suppressor. While this expectation was met in a model of oncogene-driven lymphomagenesis or carcinogen-driven tumor formation in the gut, studies on IR-driven tumor formation revealed surprising new insights into the role of p53-triggered and PUMA-mediated apoptosis in tumorigenesis and stem cell homeostasis.

PMID:
20980816
DOI:
10.4161/cc.9.21.13666
[Indexed for MEDLINE]

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