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Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a000745. doi: 10.1101/cshperspect.a000745.

DNA damage response.

Author information

1
Department of Genetics, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.

Abstract

Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity. Like transcription and replication, DDR is a chromatin-associated process that is generally tightly controlled in time and space. As DNA damage can occur at any time on any genomic location, a specialized spatio-temporal orchestration of this defense apparatus is required.

PMID:
20980439
PMCID:
PMC3003462
DOI:
10.1101/cshperspect.a000745
[Indexed for MEDLINE]
Free PMC Article

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