Polymorphisms of COMT and XPD and risk of esophageal squamous cell carcinoma in a population of Yili Prefecture, in Xinjiang, China

Biomarkers. 2011 Feb;16(1):37-41. doi: 10.3109/1354750X.2010.522732. Epub 2010 Oct 27.

Abstract

Objective: To investigate polymorphisms of COMT (Rs4680) and XPD (Rs13181) and risk of esophageal squamous cell carcinoma (ESCC) in a population from Yili Prefecture, Xinjiang, China.

Methods: A hospital-based case-control study was designed. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Odds ratios (OR) and 95% confidence intervals (CI) were analysed using unconditional logistic regression.

Results: An increased risk of ESCC was discovered with COMT in relation to the frequency of the presence of the A allele (Rs4680; OR 1.30, 95% CI 1.00-1.68). An individual with combined COMT 158 (Val/Met or Met/Met) and XPD 751 (Lys/Gln or Gln/Gln) genotype had an increased ESCC risk.

Conclusions: Polymorphic variation in COMT Val158Met and XPD Lys751Gln may be important for ESCC susceptibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Asian People / genetics*
  • Carcinoma, Squamous Cell / genetics*
  • Catechol O-Methyltransferase / genetics*
  • China / epidemiology
  • Esophageal Neoplasms / genetics*
  • Esophageal Neoplasms / pathology
  • Female
  • Gene Frequency / genetics
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Risk Factors
  • Xeroderma Pigmentosum Group D Protein / genetics*

Substances

  • Catechol O-Methyltransferase
  • Xeroderma Pigmentosum Group D Protein
  • ERCC2 protein, human