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J Atten Disord. 2012 May;16(4):295-303. doi: 10.1177/1087054710385067. Epub 2010 Oct 26.

Iron status in toddlerhood predicts sensitivity to psychostimulants in children.

Author information

1
University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.

Abstract

OBJECTIVE:

Iron deficiency is associated with impaired dopaminergic signaling and externalizing behavior. The authors examine, whether iron stores in toddlerhood influence later response to psychostimulants.

METHOD:

Youth participating in a study monitoring the long-term safety of risperidone were included in this analysis if they had received psychostimulant monotherapy for at least 3 weeks and had a complete blood count obtained before psychostimulant treatment. Sensitivity to psychostimulants was defined based on the weight-adjusted dose during the 1st year of treatment. Regression analysis examined whether the hematological tests based on the characteristics of red blood cells were associated with sensitivity to psychostimulants.

RESULTS:

A total of 29 participants (93% men; 76% Whites), primarily with ADHD (93%), comprised the current sample. The hematological tests were obtained, on average, 3 years before the initiation of psychostimulants monotherapy that occurred at 5.8 years of age and continued for a median of 0.85 years, at an average daily dose of 0.98 mg/kg (SD = 0.38) in methylphenidate equivalent. Compared with those who were poorly sensitive to psychostimulants, after adjusting for age, mean corpuscular volume was significantly higher in the highly and moderately psychostimulants sensitive groups.

CONCLUSIONS:

If replicated, these findings suggest that more attention should be paid to optimizing body iron in early childhood.

PMID:
20978274
PMCID:
PMC3556512
DOI:
10.1177/1087054710385067
[Indexed for MEDLINE]
Free PMC Article

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