Format

Send to

Choose Destination
J Neuroimaging. 2011 Oct;21(4):375-82. doi: 10.1111/j.1552-6569.2010.00515.x. Epub 2010 Oct 26.

Structural brain changes in patients with recurrent major depressive disorder presenting with anxiety symptoms.

Author information

1
GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, UK. b.inkster@imperial.ac.uk

Abstract

BACKGROUND AND PURPOSE:

Major depressive disorder (MDD) presents with extensive clinical heterogeneity. In particular, overlap with anxiety symptoms is common during depressive episodes and as a comorbid disorder. The aim of this study was to test for morphological brain differences between patients having a history of recurrent MDD with, and without, anxiety symptoms (MDD+A and MDD-A).

METHODS:

T1-weighted magnetic resonance images of age-, gender- and ethnically matched groups of MDD+A (n= 49) and MDD-A (n= 96) patients were available for voxel-based morphometry analysis of regional gray matter (GM) volume differences. Brain structural images were also contrasted with 183 age-, gender-, and ethnicity-matched healthy controls.

RESULTS:

MDD+A patients had greater GM volume (P(FWE) = .002) than MDD-A patients in the right temporal cortex extending from the mid-posterior superior temporal gyrus into the posterior middle and inferior temporal gyrus. The MDD patients together showed lower GM volume than healthy controls in the superior parietal lobe.

CONCLUSIONS:

Regional volume differences in patients are consistent with altered neuronal or glial microstructure. The temporolateral cortical differences distinguishing the 2 MDD groups suggest neurobiological differences related to the expression of anxiety symptoms in depression and provide further rationale for considering these groups independently for therapeutic outcomes studies.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center