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Curr Opin Clin Nutr Metab Care. 2010 Nov;13(6):677-84. doi: 10.1097/MCO.0b013e32833de911.

Vitamin D supplementation: a pharmacologic perspective.

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1
Division of Biobehavioral & Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania, USA. boullata@nursing.upenn.edu

Abstract

PURPOSE OF REVIEW:

Vitamin D supplementation is expected to increase as clinicians try to optimize their patients' vitamin D status. This review integrates newer information into a perspective on vitamin D disposition and effect.

RECENT FINDINGS:

Vitamin D is being considered for indications beyond bone health. The limited dose-response data vary by indication, but generally target a goal serum 25(OH)D concentration of 80-120 nmol/l. Although oral vitamin D is adequately absorbed, distributed, metabolized, and utilized before being excreted, these factors may vary with baseline vitamin D status, genetic polymorphism, and the form of vitamin D being administered. Additionally, the responses to vitamin D can be tissue-specific and are not always well described.

SUMMARY:

There is still a need to better characterize the disposition and effect of vitamin D supplementation. Data will need to be more specific to the therapeutic indication and demonstrate health outcomes. Long-term effects of high-dose supplementation at the tissue level will be especially important to describe.

PMID:
20975351
DOI:
10.1097/MCO.0b013e32833de911
[Indexed for MEDLINE]
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