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Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19396-401. doi: 10.1073/pnas.1014515107. Epub 2010 Oct 25.

FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo.

Author information

1
Department of Biology, Institute of Genetics, University of Erlangen-Nuremberg, 91058 Erlangen, Germany. fnimmerj@biologie.uni-erlangen.de

Abstract

Cellular Fcγ receptors are essential for IgG-dependent effector functions in vivo. There is convincing evidence that selective activating Fcγ receptors are responsible for the activity of individual IgG subclasses. Thus, IgG1 activity is absent in FcγRIII-deficient mice, and several studies suggest that the activity of the most potent IgG subclasses, IgG2a and IgG2b, might be dependent on either individual or a combination of activating FcγRs. To study the role of individual activating FcγRs for IgG subclass activity, we generated an FcγRIV-deficient mouse and showed that a variety of IgG2a- and IgG2b-dependent effector functions are impaired in the absence of this activating Fc receptor in models of autoimmunity and antibody-dependent cellular cytotoxicity.

PMID:
20974962
PMCID:
PMC2984189
DOI:
10.1073/pnas.1014515107
[Indexed for MEDLINE]
Free PMC Article

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