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Curr Opin Cell Biol. 2011 Feb;23(1):114-21. doi: 10.1016/j.ceb.2010.09.009. Epub 2010 Oct 23.

Building mitotic chromosomes.

Author information

1
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK.

Abstract

Mitotic chromosomes are the iconic structures into which the genome is packaged to ensure its accurate segregation during mitosis. Although they have appeared on countless journal cover illustrations, there remains no consensus on how the chromatin fiber is packaged during mitosis. In fact, work in recent years has both added to existing controversies and sparked new ones. By contrast, there has been very significant progress in determining the protein composition of isolated mitotic chromosomes. Here, we discuss recent studies of chromosome organization and provide an in depth description of the latest proteomics studies, which have at last provided us with a definitive proteome for vertebrate chromosomes.

PMID:
20974528
PMCID:
PMC3060342
DOI:
10.1016/j.ceb.2010.09.009
[Indexed for MEDLINE]
Free PMC Article
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